Postnatal lung function after prenatal steroid treatment in sheep: Effect of gender

Willet, Karen E., Jobe, Alan H., Ikegami, Machiko, Polk, Daniel, Newnham, John, Kohan, Rolland, Gurrin, Lyle and Sly, Peter D. (1997) Postnatal lung function after prenatal steroid treatment in sheep: Effect of gender. Pediatric Research, 42 6: 885-892. doi:10.1203/00006450-199712000-00027

Author Willet, Karen E.
Jobe, Alan H.
Ikegami, Machiko
Polk, Daniel
Newnham, John
Kohan, Rolland
Gurrin, Lyle
Sly, Peter D.
Title Postnatal lung function after prenatal steroid treatment in sheep: Effect of gender
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
Publication date 1997-12
Sub-type Article (original research)
DOI 10.1203/00006450-199712000-00027
Volume 42
Issue 6
Start page 885
End page 892
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Abstract The effect of fetal gender on postnatal lung function and response to prenatal steroid exposure were examined retrospectively in a group of 115 preterm lambs. Fetuses received a single intramuscular injection of 0.5 mg/kg betamethasone alone or in conjunction with L-thyroxine 48 h before delivery at 128-d gestational age. Control animals received an equivalent volume of saline. After delivery, respiratory mechanics and blood gas parameters were recorded for 40 min. Deflation pressure volume curves were constructed in excised lungs. Right upper lobes from a randomly selected subgroup of control animals were examined morphometrically. Control (saline-treated) females were able to be ventilated at lower ventilatory pressures with equivalent tidal volumes and more efficient gas exchange. There were no gender differences in compliance, conductance, or excised lung volumes for saline-treated animals. More efficient gas exchange in females could not be explained by thinner alveolar septa or greater alveolar surface area. After hormone treatment, both males and females exhibited significant improvements in respiratory mechanics, gas exchange, and an increase in alveolar surfactant concentration. However, females exhibited a significantly greater improvement than males for compliance, conductance, excised lung volume, and arterial oxygen partial pressure. These data provide a comprehensive description of gender differences in postnatal lung function and response to steroid treatment in preterm animals, and support clinical findings of sexual dimorphism.
Keyword Respiratory distress syndrome
Fetal rat lung
Hyaline membrane disease
Sex differences
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 17 Nov 2010, 11:58:45 EST