Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep

Willet, K.E., Jobe, A.H., Ikegami, M., Kovar, J. and Sly, P.D. (2001) Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep. American Journal of Respiratory and Critical Care Medicine, 163 6: 1437-1443.

Author Willet, K.E.
Jobe, A.H.
Ikegami, M.
Kovar, J.
Sly, P.D.
Title Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1073-449X
1535-4970
Publication date 2001-05
Sub-type Article (original research)
Volume 163
Issue 6
Start page 1437
End page 1443
Total pages 7
Place of publication New York, NY, United States
Publisher American Thoracic Society
Language eng
Abstract Antenatal glucocorticoids are thought to be less effective when delivery occurs more than 7 d after initiation of treatment; therefore, repeat courses are often administered. We examined lung structure after single or repetitive antenatal glucocorticoid injections in fetal sheep. Pregnant ewes received single or repetitive doses of 0.5 mg/kg betamethasone at 7-d intervals by maternal or fetal injection, beginning at D104 or D114 with delivery at D125, D135, or D146 gestation (term = 150 d). Changes in lung structure were more pronounced after repetitive versus single injections. Repetitive fetal or maternal injections beginning at D104 (delivery at D125) resulted in comparable structural changes: alveolar volume increased by 50 to 80%, alveolar numerical density decreased by 30 to 40%, and pleural and interlobular septal volumes decreased by as much as 70%. Similar changes were seen in animals delivered at D135 after repetitive maternal injections beginning at D114. There were no structural differences between control and repetitive betamethasone animals when delivery was delayed until D146, indicating that betamethasone induced structural changes were reversible.
Keyword FetalL hormone- treatrment
Controlled trial
Gestational -age
Fluid balance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:58:27 EST