Differing patterns of mechanical response to direct fetal hormone treatment

Willet, K.E., Gurrin, L., Burton, P., Lanteri, C.J., Reese, A.C., Vij, J., Matsumoto, I., Jobe, A.H., Ikegami, M., Polk, D., Newnham, J., Kohan, R., Kelly, R. and Sly, P.D. (1996) Differing patterns of mechanical response to direct fetal hormone treatment. Respiration Physiology, 103 3: 271-280. doi:10.1016/0034-5687(95)00095-X

Author Willet, K.E.
Gurrin, L.
Burton, P.
Lanteri, C.J.
Reese, A.C.
Vij, J.
Matsumoto, I.
Jobe, A.H.
Ikegami, M.
Polk, D.
Newnham, J.
Kohan, R.
Kelly, R.
Sly, P.D.
Title Differing patterns of mechanical response to direct fetal hormone treatment
Journal name Respiration Physiology   Check publisher's open access policy
ISSN 0034-5687
Publication date 1996-03
Sub-type Article (original research)
DOI 10.1016/0034-5687(95)00095-X
Volume 103
Issue 3
Start page 271
End page 280
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract A single combined intramuscular dose of betamethasone and l-thyroxine (T4) or placebo was injected into the shoulder of fetal lambs 48 hours prior to delivery at days 121 (n = 14), 128 (n = 25) or 135 (n = 20) of gestation. Respiratory mechanics were calculated using multiple linear regression analysis. Both respiratory system resistance (R(RS)) and elastance (E(RS)) decreased approximately 4 fold between gestational days 121 (D121) and 135 (D135). Both variables were also reduced by hormone treatment. Reduction in E(RS) was due to a reduction in both lung (E(L)) and chest wall (E(W)) components. In absolute terms E(W) decreased with gestational age; however, E(W) as a proportion of total elastance (% E(W)) increased. Inclusion of a volume-dependent elastance term in the multiple linear regression model enabled us to separate total elastance into volume-independent (E1) and volume-dependent (E2V) components. E1 decreased almost 8-fold compared with only a 2.5-fold fall in E2V between D121 and D135. %E2, the proportion of E(RS) which is volume-dependent and which provides an index of overventilation, doubled over this time period. Hormone treatment affected E1 and E2V components equally hence %E2 was not altered. Both excised lung volume and end expiratory alveolar volume increased with gestational age and with treatment. The response to treatment was qualitatively similar at each of the gestational ages examined, however, for all mechanics variables, except resistance and E1, the magnitude of response to treatment was significantly smaller in D135 animals compared with other age groups.
Keyword Development, gestation, respiratory mechanics
Hormones, betamethasone, 1-thyroxine
Mammals, lamb, fetal
Mechanics of breathing, gestations, hormones
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Nov 2010, 11:58:21 EST