Early-onset atopy is associated with enhanced lymphocyte cytokine responses in 11-year-old children

Turner, S. W., Heatonw, T., Rowew, J., Suriyaarachchi, D., Serralha, M., Holt, B. J.., Franklin, P. J., Stick, S. M., Goldblatt, J., Sly, P. D., le Souef, P. N. and Holt, P. G. (2007) Early-onset atopy is associated with enhanced lymphocyte cytokine responses in 11-year-old children. Clinical And Experimental Allergy, 37 3: 371-380. doi:10.1111/j.1365-2222.2007.02668.x

Author Turner, S. W.
Heatonw, T.
Rowew, J.
Suriyaarachchi, D.
Serralha, M.
Holt, B. J..
Franklin, P. J.
Stick, S. M.
Goldblatt, J.
Sly, P. D.
le Souef, P. N.
Holt, P. G.
Title Early-onset atopy is associated with enhanced lymphocyte cytokine responses in 11-year-old children
Journal name Clinical And Experimental Allergy   Check publisher's open access policy
ISSN 0954-7894
Publication date 2007-03
Sub-type Article (original research)
DOI 10.1111/j.1365-2222.2007.02668.x
Volume 37
Issue 3
Start page 371
End page 380
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract Background: Early age at onset of atopy is associated with more severe asthma and increased airway responsiveness (AR); the underlying mechanism is unclear but may involve T cell responses. Objective: To test the hypothesis that enhanced T cell responses may be associated with early-onset atopy. Methods: In a longitudinal study, atopy was determined in infancy and at 6 and 11 years of age. Individuals were categorized as persistent infant-onset atopy (PIOA), early childhood-onset atopy (ECOA) and later childhood-onset atopy (LCOA). At 11 years of age, peripheral blood T cell cytokine responses, AR, exhaled nitric oxide (FENO) and forced expiratory volume in 1 s were determined. Results: The age at onset of atopy was determined for 60 children, of whom 15 had PIOA, 24 had ECOA and 21 had LCOA. An additional 76 children who were never atopic were also included. T cell responses to house dust mite, including interleukin-5, -9, -10 and tumour necrosis factor α, were higher among children with PIA and ECOA, and lower in children with LCOA, P<0.05. In contrast, those children with LCOA or who were not atopic had the highest IL-10 response to PHA (P=0.014). Children with PIOA and ECOA, but not LCOA, had higher AR and FENO compared with non-atopic children (P<0.05). The group with PIOA were more likely among the atopic children to be admitted to hospital for asthma (P<0.05) and also had lower %FEV1 compared with non-atopic children (P=0.023). Conclusions: Early age at sensitization is associated with enhanced T cell cytokine responses and indices of adverse asthma outcome. T cell cytokine responses might be programmed at the time of initial atopic sensitization.
Keyword Airway responsiveness
Longitudinal studies
Skin tests
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Nov 2010, 11:55:21 EST