Site of action of hypertonic saline in the canine lung

Sly, P. D. and Lanteri, C. J. (1991) Site of action of hypertonic saline in the canine lung. Journal of Applied Physiology, 71 4: 1315-1321.

Author Sly, P. D.
Lanteri, C. J.
Title Site of action of hypertonic saline in the canine lung
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
1522-1601
Publication date 1991-10
Sub-type Article (original research)
Volume 71
Issue 4
Start page 1315
End page 1321
Total pages 7
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract The site of action of inhaled hypertonic saline was determined in 8- to 10-wk-old puppies by combining measurements of respiratory mechanics, made during mechanical ventilation and after midexpiratory flow interruptions, with direct measurements of alveolar pressure. Under both control conditions and after inhalation of 10% saline, we were able to partition lung mechanics into components representing the airways and tissue viscoelastic properties. Hypertonic saline challenge altered lung mechanics by increasing airway resistance and did not have any effect on elastic or viscoelastic properties of the lung.
Keyword Alveolar pressure
Bronchoprovocation
Interrupter technique
Viscoelasticity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 11:50:46 EST