Differential responses of the airways and pulmonary tissues to inhaled histamine in young dogs

Sly, P. D. and Lanteri, C. J. (1990) Differential responses of the airways and pulmonary tissues to inhaled histamine in young dogs. Journal of Applied Physiology, 68 4: 1562-1567.

Author Sly, P. D.
Lanteri, C. J.
Title Differential responses of the airways and pulmonary tissues to inhaled histamine in young dogs
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
1522-1601
Publication date 1990-04
Sub-type Article (original research)
Volume 68
Issue 4
Start page 1562
End page 1567
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract Airway and pulmonary tissue responses to aerosolized histamine were studied in five mongrel puppies (8-10 wk old). Alveolar pressure was measured by use of alveolar capsules and respiratory mechanics calculated during tidal ventilation and flow interruptions. Aerosolized histamine caused an increase in the tissue viscoelastic properties, which was measured as an increase in pulmonary resistance during tidal ventilation. An increase in stress recovery of the pulmonary tissues was measured with the interrupter technique after aerosolized histamine. These data demonstrate that aerosolized histamine causes an increase in the tissue viscoelastic properties. The most reasonable explanation for the mechanism of this increase would seem to be via reflex pathways stimulated by centrally located receptors.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 11:50:37 EST