Failure of ipratropium brominde to modify the diurnal variation of asthma in asthmatic children

Sly, P.D., Landau, L.I. and Olinsky, A. (1987) Failure of ipratropium brominde to modify the diurnal variation of asthma in asthmatic children. Thorax, 42 5: 357-360. doi:10.1136/thx.42.5.357


Author Sly, P.D.
Landau, L.I.
Olinsky, A.
Title Failure of ipratropium brominde to modify the diurnal variation of asthma in asthmatic children
Journal name Thorax   Check publisher's open access policy
ISSN 0040-6376
1468-3296
Publication date 1987-05
Sub-type Article (original research)
DOI 10.1136/thx.42.5.357
Volume 42
Issue 5
Start page 357
End page 360
Total pages 4
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Thirty one children with asthma were given 40 μg of ipratropium bromide and identical placebo by inhalation three times a day in a double blind, randomised crossover study to test the ability of an anticholinergic drug to modify the diurnal variation in airway calibre and bronchial reactivity. Subjects measured peak expiratory flow rate approximately eight hourly, before and after inhaled salbutamol, for four week period. Paired t tests and cosinor analysis were used to assess the diurnal variation in airway calibre from the peak expiratory flow rate recorded before salbutamol and to assess the diurnal variation in bronchodilator responsiveness from the increase in peak expiratory flow rate after salbutamol. Maintenance treatment with ipratropium bromide 40 μg three times daily reduced the provocative dose of histamine which caused a 20% fall in FEV1 (geometric mean PD20 = 0.78 v 0.49 mg/ml, p < 0.05), despite an eight to 12 hour gap between the last dose of ipratropium and histamine challenge. It did not, however, diminish the diurnal variation in airway calibre (mean amplitude = 12.7 v 10.1) or in bronchodilator responsiveness (mean amplitude = 62.4 v 63.5). There was no improvement in the clinical state of subjects while they were taking ipratropium bromide.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:50:26 EST