Frequency-dependent effects of hypercapnia on respiratory mechanics of cats

Sly, P. D., Bates, J. H. T., Kochi, T., Okubo, S. and Milicemili, J. (1987) Frequency-dependent effects of hypercapnia on respiratory mechanics of cats. Journal of Applied Physiology, 62 2: 444-450.

Author Sly, P. D.
Bates, J. H. T.
Kochi, T.
Okubo, S.
Milicemili, J.
Title Frequency-dependent effects of hypercapnia on respiratory mechanics of cats
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 1987-02
Sub-type Article (original research)
Volume 62
Issue 2
Start page 444
End page 450
Total pages 7
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Formatted abstract
The effect of increasing arterial partial pressure of CO2 (Pa(CO2)) on respiratory mechanics was investigated in six anesthetized, paralyzed cats ventilated by constant-flow inflation. Respiratory mechanics were studied after end-inspiratory occlusions. Zero frequency resistance (Rmax), infinite frequency resistance (Rmin), and static elastance (Est) were calculated for the respiratory system, lung, and chest wall. Alveolar ventilation was manipulated by the addition of dead space to achieve a range of Pa(CO2) values of 29.3-87.3 mmHg. Cats did not become hypoxic during the experiment. Under control conditions marked frequency dependence in Rmax, Rmin, and Est of the respiratory system, lungs, and chest wall was demonstrated. The chest wall contributed 50% of the total resistance of the respiratory system. With increasing Pa(CO2) the only resistance observed to increase was Rmax of the lung (P < 0.01). There were also no changes in the static elastic properties of either the lungs or the chest wall. These results suggest that hypercapnia increases resistance by changes in the lung periphery and not in the conducting airways.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Created: Wed, 17 Nov 2010, 11:47:56 EST