Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma

Romieu, Isabelle, Barraza-Villarreal, Albino, Escamilla-Nunez, Consuelo, Almstrand, Ann-Charlotte, Diaz-Sanchez, David, Sly, Peter D. and Olin, Anna-Carin (2008) Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. Journal of Allergy and Clinical Immunology, 121 4: 903-909. doi:10.1016/j.jaci.2007.12.004


Author Romieu, Isabelle
Barraza-Villarreal, Albino
Escamilla-Nunez, Consuelo
Almstrand, Ann-Charlotte
Diaz-Sanchez, David
Sly, Peter D.
Olin, Anna-Carin
Title Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
1085-8725
1097-6825
Publication date 2008-04
Sub-type Article (original research)
DOI 10.1016/j.jaci.2007.12.004
Volume 121
Issue 4
Start page 903
End page 909
Total pages 7
Place of publication Milwaukee, WI, United States
Publisher Mosby
Language eng
Abstract Background: Assessment of the adverse effects of oxidative stress related to air pollution is limited by the lack of biological markers of dose to the lungs. Objective: We evaluated the use of exhaled breath condensate (EBC) malondialdehyde as a biomarker of exposure to traffic-related pollution in children with asthma as part of a panel study in Mexico City. Methods: Standard spirometry and collection of EBC and nasal lavage were performed. Environmental monitoring sites were located within 5 km of the children's homes and schools. Data were analyzed by using generalized estimating equations. Results: A total of 480 samples of malondialdehyde were obtained from 107 patients with asthma, with a median level of 18.7 (interquartile range [IQR], 12.4-28.7) nmol. Ambient particulates less than 2.5 μg/m3 and ozone levels on the day of sampling were significantly associated with higher malondialdehyde levels. A 14.2-μg/m3 (IQR) increase in 8-hour moving average particulates less than 2.5 μg/m3 in size was associated with a 1.12-nmol increase in malondialdehyde and a 15.9-ppb (IQR) increase in 8-hour moving average ozone with a 1.16-nmol increase in malondialdehyde. Malondialdehyde levels were inversely associated with forced vital capacity and FEV1 and positively associated with IL-8 levels in nasal lavage. Conclusion: Exhaled breath condensate malondialdehyde was related to both air pollution exposure and changes in lung function and inflammatory markers.
Keyword asthma
clinical immunology
environment
epidemiology
pediatrics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 11:44:52 EST