Duodenal pH in cystic fibrosis and its relationship to fat malabsorption

Robinson, P.J., Smith, A.L. and Sly, P.D. (1990) Duodenal pH in cystic fibrosis and its relationship to fat malabsorption. Digestive Diseases and Sciences, 35 10: 1299-1304. doi:10.1007/BF01536423

Author Robinson, P.J.
Smith, A.L.
Sly, P.D.
Title Duodenal pH in cystic fibrosis and its relationship to fat malabsorption
Journal name Digestive Diseases and Sciences   Check publisher's open access policy
ISSN 0163-2116
Publication date 1990-10
Sub-type Article (original research)
DOI 10.1007/BF01536423
Volume 35
Issue 10
Start page 1299
End page 1304
Total pages 6
Place of publication New York, NY, United States
Publisher Springer
Language eng
Abstract To investigate the relationship between duodenal pH levels and supplemental pancreatic enzyme function in cystic fibrosis, 18 children with this condition had pH recordings performed from the second and fourth part of the duodenum. Compared to age-matched controls, patients with cystic fibrosis had significantly longer periods below a pH of 4.0 in the postprandial period and significantly less time above pH 5.8. These values correspond to the pH levels at which lipase is irreversibly destroyed (pH 4.0) and enteric coating of enzyme supplements dissolves (pH 5.8). A significant relationship was found between the pH recordings from the fourth part of the duodenum and the degree of residual fat malabsorption while taking enteric-coated enzyme supplements. Four patients with an excessively acidic duodenum and residual fat malabsorption despite high-dose enzyme supplementation were treated with misoprostol (Searle), a known acid-reducing agent. There were significant improvements in both duodenal pH values and fat absorption. We conclude that there is a wide range of duodenal pH values found in patients with cystic fibrosis and that the efficiency with which enzyme supplements work is closely related to these pH levels. Administration of misoprostol to those patients with excessively acidic duodenal pH levels as well as residual malabsorption appears to be of benefit in improving both the excessively acidic pH levels and the fat malabsorption.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 57 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 67 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 17 Nov 2010, 11:44:36 EST