Postnatal lung function in preterm lambs: Effects of a single exposure to betamethasone and thyroid hormones

Polk, Daniel H., Ikegami, Machiko, Jobe, Alan H., Newnham, John, Sly, Peter, Kohen, Rolland and Kelly, Robert (1995) Postnatal lung function in preterm lambs: Effects of a single exposure to betamethasone and thyroid hormones. American Journal of Obstetrics and Gynecology, 172 3: 872-881. doi:10.1016/0002-9378(95)90014-4


Author Polk, Daniel H.
Ikegami, Machiko
Jobe, Alan H.
Newnham, John
Sly, Peter
Kohen, Rolland
Kelly, Robert
Title Postnatal lung function in preterm lambs: Effects of a single exposure to betamethasone and thyroid hormones
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 1995-03
Sub-type Article (original research)
DOI 10.1016/0002-9378(95)90014-4
Volume 172
Issue 3
Start page 872
End page 881
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Objective:
We determined the effect of a single direct fetal injection of corticosteroid and thyroid hormones on postnatal pulmonary function in preterm lambs.

Study design:
Initially fetal sheep (126 days' gestation) randomly received saline solution, betamethasone (Celestone Soluspan, 0.5 mg/kg), betamethasone plus triiodothyronine (5 μg/kg), or betamethasone plus thyroxine (15 μg/kg) as a single injection. Forty-eight hours later (128 days' gestation) the fetuses were delivered and ventilated for 50 minutes. In a second protocol fetuses were delivered at 128 days' gestation, after only 24 hours of hormone exposure.

Results:
Betamethasone treatment improved compliance nearly twofold after 24 or 48 hours of exposure. Efficiency of ventilation also improved after steroid therapy; this effect was augmented 48 hours after thyroxine exposure (but not triiodothyronine). No thyroxine effect was noted after 24 hours of exposure. Maximal lung volume increased by 80% after steroid treatment and doubled in response to combination betamethasone and thyroxine therapy. Alveolar pool sizes of saturated phosphatidylcholine and surfactant protein A were comparable for all groups exposed for 48 hours.

Conclusions:
A single fetal exposure to betamethasone improves postnatal pulmonary function after 24 or 48 hours. Addition of thyroxine (but not triiodothyronine) augments this effect at 48 hours.
Keyword Fetal therapy
Maturation
Pulmonary adaptation
Sheep
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 18 May 2004.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:43:37 EST