Effects of gestation and antenatal steroid on airway and tissue mechanics in newborn lambs

Pillow, J.J., Hall, G.L., Willet, K.E., Jobe, A.H., Hantos, Z. and Sly, P.D. (2001) Effects of gestation and antenatal steroid on airway and tissue mechanics in newborn lambs. American Journal of Respiratory and Critical Care Medicine, 163 5: 1158-1163.

Author Pillow, J.J.
Hall, G.L.
Willet, K.E.
Jobe, A.H.
Hantos, Z.
Sly, P.D.
Title Effects of gestation and antenatal steroid on airway and tissue mechanics in newborn lambs
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1073-449X
1535-4970
Publication date 2001-04
Sub-type Article (original research)
Volume 163
Issue 5
Start page 1158
End page 1163
Total pages 6
Place of publication New York, NY, United States
Publisher American Thoracic Society
Language eng
Abstract The aim of this study was to partition airway and parenchymal mechanics in newborn lambs at different gestations and following variable exposure to antenatal maternal betamethasone using the forced oscillation technique (FOT). Pulmonary impedance data were collected in 37 sedated and intubated apneic lambs with the FOT between 0.5 and 20 Hz and fitted by a model to estimate airway resistance (Raw) and inertance (Iaw) and the coefficients of tissue resistance (GL) and elastance (HL). Total respiratory resistance (Rrs) was also determined during tidal ventilation by using the multiple linear regression technique. Advancing gestation or increasing antenatal steroid exposure had no clinically significant effect on the values of Raw and Iaw, whereas Rrs and both GL and HL decreased markedly. There was a decrease in tissue hysteresivity (GL/HL) with repeated antenatal steroid exposure. Partitioning of lung mechanics highlights the dominant contribution of the tissues to the total respiratory resistance in the immature ovine lung. Clinically relevant changes in lung mechanics associated with structural and functional maturation of the immature ovine lung are primarily confined to the tissue compartment.
Keyword Fetal hormone treatment
Human lung growth
Bronchopulmonary dysplasia
Respiratory system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:42:26 EST