Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children

Pereira, M. U., Sly, P. D., Pitrez, P. M., Jones, M. H., Escouto, D., Dias, A. C. O., Weiland, S. K. and Stein, R. T. (2007) Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children. European Respiratory Journal, 29 6: 1154-1160. doi:10.1183/09031936.00127606

Author Pereira, M. U.
Sly, P. D.
Pitrez, P. M.
Jones, M. H.
Escouto, D.
Dias, A. C. O.
Weiland, S. K.
Stein, R. T.
Title Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2007-06
Sub-type Article (original research)
DOI 10.1183/09031936.00127606
Volume 29
Issue 6
Start page 1154
End page 1160
Total pages 7
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Abstract Asthma is common in urban centres in Latin America, but atopic asthma may not be the main phenotype among children. Helminth infections are highly prevalent in poor populations, and it was hypothesised that they attenuate allergic asthma, whereas other factors are related to the expression of a nonatopic wheeze/asthma phenotype. A total of 1,982 children from Southern Brazil with a mean ± SD age of 10.1 ± 0.76 yrs completed asthma questionnaires, and 1,011 were evaluated for intestinal parasites and atopy using skin-prick tests (SPTs). Wheeze in the previous 12 months was reported by 25.6%, and 9.3% showed current asthma; 13% were SPT-positive and 19.1% were positive for any helminths. Most children with either wheeze or asthma were SPT-negative; however, severe wheeze was more prevalent among the atopic minority. Helminth infections were inversely associated with positive SPT results. Bronchiolitis before the age of 2 yrs was the major independent risk factor for asthma at age 10 yrs; high-load Ascaris infection, a family history of asthma and positive SPT results were also asthma risk factors. Most asthma and wheeze are of the nonatopic phenotype, suggesting that some helminths may exert an attenuating effect on the expression of the atopic portion of the disease, whereas viral bronchiolitis predisposes more specifically to recurrent airway symptoms.
Keyword allergy
intestinal parasites
nonatopic asthma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Created: Wed, 17 Nov 2010, 11:41:08 EST