CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis

Martin, A. C., Laing, I. A., Zhang, G., Brennan, S., Winfield, K., Sly, P. D., Stick, S. M., Goldblatt, J. and Lesouef, P. N. (2005) CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis. Respiratory Research, 6 Article #63: . doi:10.1186/1465-9921-6-63


Author Martin, A. C.
Laing, I. A.
Zhang, G.
Brennan, S.
Winfield, K.
Sly, P. D.
Stick, S. M.
Goldblatt, J.
Lesouef, P. N.
Title CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis
Journal name Respiratory Research   Check publisher's open access policy
ISSN 1465-9921
Publication date 2005-06
Sub-type Article (original research)
DOI 10.1186/1465-9921-6-63
Open Access Status DOI
Volume 6
Issue Article #63
Total pages 4
Place of publication United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Early acquisition of Pseudomonas aeruginosa is associated with a poorer prognosis in patients with cystic fibrosis. We investigated whether polymorphisms in CD14, the lipopolysaccharide receptor, increase the risk of early infection. Forty-five children with cystic fibrosis were investigated with annual bronchoalveolar lavage (BAL) and plasma sCD14 levels. Plasma sCD14 levels were significantly lower in children from whom P.aeruginosa was subsequently isolated (492.75 μg/ml vs. 1339.43 μg/ml, p = 0.018). Those with the CD14 -159CC genotype had a significantly increased risk of early infection with P.aeruginosa suggesting that CD14 C-159T plays a role in determining the risk of early infection with P.aeruginosa.
Keyword Cystic fibrosis (CF)
Pseudomonas aeruginosa
CD14
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
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Created: Wed, 17 Nov 2010, 11:38:31 EST