Effect of chloral hydrate on arterial oxygen saturation in wheezy infants

Mallol, J. and Sly, P.D. (1988) Effect of chloral hydrate on arterial oxygen saturation in wheezy infants. Pediatric Pulmonology, 5 2: 96-99. doi:10.1002/ppul.1950050206


Author Mallol, J.
Sly, P.D.
Title Effect of chloral hydrate on arterial oxygen saturation in wheezy infants
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
1099-0496
Publication date 1988
Sub-type Article (original research)
DOI 10.1002/ppul.1950050206
Volume 5
Issue 2
Start page 96
End page 99
Total pages 4
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Chloral hydrate is commonly used to sedate infants for pulmonary function tests and other investigations. However, sedation is generally not recommended for infants with acute wheezing illnesses. The commonly used dose range exceeds the maximum recommended dose; however, the effects of this dosage regimen during pulmonary function testing have not been studied. The present study shows that 70-100 mg/kg of chloral hydrate, a dose commonly used to sedate infants for pulmonary function testing, causes a fall in arterial oxygen saturation and a decrease in clinical score of infants recovering from acute viral bronchiolitis, but not in infants with clinically stable cystic fibrosis. These findings suggest that wheezy infants with baseline SaO2 less than or equal to 94% are more susceptible to central respiratory depression following sedation with chloral hydrate. The results of the present study raise serious doubts about the advisability of sedation with chloral hydrate, in the currently used doses, in wheezy infants.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:38:20 EST