Primary sensitization to inhalant allergens

Macaubas, Claudia, Prescott, Susan L., Venaille, Thierry J., Holt, Barbara J., Smallacombe, Troy B., Sly, Peter D. and Holt, Patrick G. (2000) Primary sensitization to inhalant allergens. Pediatric Allergy and Immunology, 11 9-11. doi:10.1034/j.1399-3038.2000.00502.x


Author Macaubas, Claudia
Prescott, Susan L.
Venaille, Thierry J.
Holt, Barbara J.
Smallacombe, Troy B.
Sly, Peter D.
Holt, Patrick G.
Title Primary sensitization to inhalant allergens
Journal name Pediatric Allergy and Immunology   Check publisher's open access policy
ISSN 0905-6157
1399-3038
Publication date 2000-09
Sub-type Article (original research)
DOI 10.1034/j.1399-3038.2000.00502.x
Volume 11
Start page 9
End page 11
Total pages 2
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The neonatal T-cell system is capable of responding to allergens at birth, indicating the occurrence of prenatal sensitization, and the cytokine profile of these responses is skewed towards the Th-2 type. This response is further modified by postnatal exposure to different types of allergens. In relation to inhalant allergen (employed by HDM) the low level fetal Th-2 responses in non-atopics appear to be down-regulated rapidly after birth, parallel to an increase in allergen-specific IFN-γ production. In contrast, atopics appear to consolidate their initial Th-2 responses, and around the age of 6 exhibit a cytokine response profile similar to the adult pattern. A pre-existing deficiency in IFN-γ production may be one of the key factors determining the postnatal persistence of Th-2 responses in atopics.
Keyword Allergy
Infancy
Cytokines
Th1/Th-2
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:38:03 EST