Absence of cholinergic airway tone in normal BALB/c mice

Larcombe, Alexander N., Zosky, Graeme R., Bozanich, Elizabeth M., Turner, Debra J., Hantos, Zoltan and Sly, Peter D. (2008) Absence of cholinergic airway tone in normal BALB/c mice. Respiratory Physiology and Neurobiology, 161 3: 223-229. doi:10.1016/j.resp.2008.01.009

Author Larcombe, Alexander N.
Zosky, Graeme R.
Bozanich, Elizabeth M.
Turner, Debra J.
Hantos, Zoltan
Sly, Peter D.
Title Absence of cholinergic airway tone in normal BALB/c mice
Journal name Respiratory Physiology and Neurobiology   Check publisher's open access policy
ISSN 1569-9048
Publication date 2008-05-31
Sub-type Article (original research)
DOI 10.1016/j.resp.2008.01.009
Volume 161
Issue 3
Start page 223
End page 229
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Basal airway smooth muscle (ASM) tone has not been demonstrated in mice in vivo. To determine whether basal ASM tone is present in mouse airways we measured respiratory system impedance (Zrs) before and after either atropine or bilateral vagotomy. Zrs was measured using forced oscillations delivered via a wave-tube during slow (not, vert, similar35 s) inflation–deflation maneuvers between transrespiratory pressures (Prs) of 0 and 20 cm H2O. A constant-phase tissue model was applied to the Zrs to calculate airway resistance (Raw), tissue damping (G) and elastance (H). Thoracic gas volume (TGV) was determined plethysmographically at Prs = 0 cm H2O and by integration of the inspiratory flow. The relationship between conductance (Gaw = 1/Raw) and TGV during inflation was also examined. Neither atropine nor vagotomy produced any change in Raw, H, η (=G/H), TGV or the slope of Gaw vs. TGV that was different to that observed in the relevant control groups. These data show that BALB/c mice do not have cholinergic ASM tone in vivo.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 17 Nov 2010, 11:37:15 EST