Changes in respiratory mechanics with age

Lanteri, C. J. and Sly, P. D. (1993) Changes in respiratory mechanics with age. Journal of Applied Physiology, 74 1: 369-378.

Author Lanteri, C. J.
Sly, P. D.
Title Changes in respiratory mechanics with age
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 1993-01
Sub-type Article (original research)
Volume 74
Issue 1
Start page 369
End page 378
Total pages 10
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Formatted abstract
A cross-sectional survey involving 51 children, ranging in age from 3 wk to 15 yr, was performed to examine the changes in respiratory mechanics with age in mechanically ventilated children, using both a single-compartment model of the respiratory system and a more sophisticated two-compartment model. Children were studied while under anesthesia for urological surgery and were considered to have normal lungs. They were paralyzed and mechanically ventilated throughout measurements. Respiratory mechanics were measured during ventilation by applying a single-compartment model and by using multilinear regression to calculate dynamic compliance and respiratory system resistance (Rrs). We then used the interrupter technique, which allowed us to partition Rrs into airway resistance and a tissue viscoelastic component known as Pdif. A static volume-pressure curve was constructed from multiple occlusions made at different lung volumes throughout expiration, and static compliance was determined. Rrs and airway resistance decreased as height increased. There was a progressive increase in respiratory system compliance with height. Pdif fell in the first 2 yr of life and then subsequently increased after the age of ~5 yr.
Keyword Children
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Created: Wed, 17 Nov 2010, 11:37:06 EST