Support for 2 variants of eczema

Kusel, Merci M. H., Holt, Patrick G., de Klerk, Nicholas and Sly, Peter D. (2005) Support for 2 variants of eczema. Journal of Allergy And Clinical Immunology, 116 5: 1067-1072. doi:10.1016/j.jaci.2005.06.038


Author Kusel, Merci M. H.
Holt, Patrick G.
de Klerk, Nicholas
Sly, Peter D.
Title Support for 2 variants of eczema
Journal name Journal of Allergy And Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
1085-8725
1097-6825
Publication date 2005-11
Sub-type Article (original research)
DOI 10.1016/j.jaci.2005.06.038
Volume 116
Issue 5
Start page 1067
End page 1072
Total pages 6
Place of publication Milwaukee, WI, United States
Publisher Mosby
Language eng
Abstract Background Studies investigating the natural history and risk factors for eczema have historically considered eczema as a single entity, without regard for the individual's atopic status. The association between atopy and eczema is complex, and as many as ⅔ of patients with eczema are not atopic. Objective To investigate the risk factors for eczema in relation to the child's atopic status in a cohort of high-risk children. Methods A prospective birth cohort of 263 children was followed for 5 years and closely examined for eczema. Antenatal and postnatal data on environmental exposures were collected by interview. Skin prick test to define atopic status was performed at 6 months and 2 and 5 years of age. Results Of the subjects, 66.1% had eczema in the first 5 years, and the majority (85.5%) reported onset of rash in the first year. A third of those with eczema were not atopic (nonatopic/intrinsic eczema). Children with atopic eczema (extrinsic eczema) were more likely to be male, to have been breast-fed longer, and to have a history of food allergies, allergic rhinitis, and current wheeze. Nonatopic eczema was more common in girls, and an association was found with early daycare attendance. Conclusion This study supports the presence of 2 variants of eczema: atopic eczema occurring early in childhood and nonatopic eczema with early daycare attendance. It is likely that environmental factors have a different effect on these 2 variants of eczema, and future studies should thus consider eczema as 2 variants in determining the effect of attributable risks.
Keyword eczema
atopiclextrinsic
nonatopiclintrinsic
risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 11:36:15 EST