Postnatal lung function in lambs after fetal hormone treatment: Effects of gestational age

Ikegami, M., Polk, D.H., Jobe, A.H., Newnham, J., Sly, P., Kohen, R. and Kelly, R. (1995) Postnatal lung function in lambs after fetal hormone treatment: Effects of gestational age. American Journal of Respiratory and Critical Care Medicine, 152 4: 1256-1261.

Author Ikegami, M.
Polk, D.H.
Jobe, A.H.
Newnham, J.
Sly, P.
Kohen, R.
Kelly, R.
Title Postnatal lung function in lambs after fetal hormone treatment: Effects of gestational age
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1073-449X
1535-4970
Publication date 1995-10
Sub-type Article (original research)
Volume 152
Issue 4
Start page 1256
End page 1261
Total pages 6
Place of publication New York, NY, United States
Publisher American Thoracic Society
Language eng
Formatted abstract
We previously found that a single dose of betamethasone in combination with thyroxine given by intramuscular injection to fetal sheep 48 h before preterm delivery at 128 d gestation improved postnatal lung function. We have now asked how the combination of 0.5 mg/kg betamethasone and 15 μg/kg T4 given by a single fetal intramuscular injection changes lung response 48 h after treatment at 121 and 135 d gestation. At 121 d gestation the fetal hormone treatment significantly improved postnatal lung function. Compliance increased by 55%, arterial PO2 increased from 39 to 215 mm Hg, PCO2 decreased from 109 to 79 mm Hg, and maximal lung volumes increased by 112%. The hormone treatment decreased the severity of the respiratory failure, although these very preterm lambs still had severe respiratory failure. At 135 d gestation, the fetal hormone treatment decreased the ventilatory pressure requirements that were needed to normalize PCO2 values from 30 to 21 cm H2O. Compliance increased by 40%, and maximal lung volumes increased by 33%. Alveolar or lung tissue, saturated phosphatidylcholine, or alveolar SP-A pool sizes did not change with hormone treatment at 135 d gestation. We conclude that fetal hormone treatment significantly improved postnatal lung function at both gestational ages, although the characteristics of the responses were different.
Keyword Thyrotropin releasing hormone
Pulmonary surfactants
Premature lambs
Sheep
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:33:14 EST