Atopic versus infectious diseases in childhood: a question of balance?

Holt, P.G., Sly, P.D and Bjorksten, B. (1997) Atopic versus infectious diseases in childhood: a question of balance?. Pediatric Allergy and Immunology, 8 2: 53-58. doi:10.1111/j.1399-3038.1997.tb00145.x

Author Holt, P.G.
Sly, P.D
Bjorksten, B.
Title Atopic versus infectious diseases in childhood: a question of balance?
Journal name Pediatric Allergy and Immunology   Check publisher's open access policy
ISSN 0905-6157
Publication date 1997-05
Sub-type Article (original research)
DOI 10.1111/j.1399-3038.1997.tb00145.x
Volume 8
Issue 2
Start page 53
End page 58
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract There is an increasing interest in the concept that respiratory tract infections during early childhood may in some circumstances confer protection against sensitisation to aeroallergens, via 'bystander' stimulation of Th-1 associated immune functions in the regional lymph nodes draining the air way mucosa. We hypothesise below that this phenomenon may be but one component of a broader process operative during early postnatal life, in which generalised contact with the microbial environment plays an obligatory role in stimulating the functional maturation of the Th-1 arm of the immune response. We argue further that one of the most potent sources of such stimulation is provided by the normal commensal flora of the gastrointestinal tract, which is establish during early infancy.
Keyword Atopy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 17 Nov 2010, 11:32:13 EST