The role of allergy in the development of asthma

Holt, P.G., Macaubas, C., Stumbles, P.A. and Sly, P.D. (1999) The role of allergy in the development of asthma. Nature, 402 6760 Supp.1: B12-B17.

Author Holt, P.G.
Macaubas, C.
Stumbles, P.A.
Sly, P.D.
Title The role of allergy in the development of asthma
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 1999-11
Sub-type Critical review of research, literature review, critical commentary
Volume 402
Issue 6760 Supp.1
Start page B12
End page B17
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Recent studies have shown that initial sensitization to airborne environmental allergens occurs typically in early childhood, but subsequent progression to persistent atopic asthma, which may not manifest for several years, is restricted to only a subset of atopics. The key to establishing the link between atopy and asthma lies in the development of persistent inflammation in the airway wall, resulting in structural and functional changes in local tissues which are responsible for the symptoms of the disease. This review summarizes recent findings on the nature of the cellular and molecular mechanisms underlying this process, and addresses the issue of why the intensity and duration of these tissue-damaging responses in the airway wall apparently exceeds the critical threshold required for development of persistent asthma in only a minority of allergy sufferers.
Keyword T-cell activation
Dendritic cells
Environmental allergens
Airway inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:30:45 EST