Influence of driving pressure on raised-volume forced expiration in infants

Hayden, M.J., Sly, P.D., Devadason, S.G., Gurrin, L.C., Wildhaber, J.H. and LeSouef, P.N. (1997) Influence of driving pressure on raised-volume forced expiration in infants. American Journal of Respiratory and Critical Care Medicine, 156 6: 1876-1883.

Author Hayden, M.J.
Sly, P.D.
Devadason, S.G.
Gurrin, L.C.
Wildhaber, J.H.
LeSouef, P.N.
Title Influence of driving pressure on raised-volume forced expiration in infants
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1073-449X
Publication date 1997-12
Sub-type Article (original research)
Volume 156
Issue 6
Start page 1876
End page 1883
Total pages 8
Place of publication New York, NY, United States
Publisher American Thoracic Society
Language eng
Formatted abstract
The raised-volume forced-expiration technique measures infant lung function over an extended volume range. To improve comparisons between individuals and populations, we investigated the influence of jacket pressure on outcome variables in 21 infants. To quantify pressure transmitted from the jacket to the pleural space at a given lung volume, the jacket was inflated against an occluded airway, and the increase in pressure at the mouth was measured. Flow-volume curves were recorded at transmitted pressure (Ptrans) values ranging from 0 to 41.9 cm H2O. The effect of Ptrans on the FEV measures of FEV0.5, FEV0.75, and FVC, and on the forced expiratory flow measures of FEF(25%), FEF(50%) and FEF(75%) was assessed. At Ptrans values between 0 to 20 cm H2O, a significant positive relationship existed between transmitted pressure (Ptrans) and all outcome variables except FVC. At higher Ptrans values, all outcome variables demonstrated pressure independence, with the exception of FEF(25%) (which remained positive) and FVC (which was negative in a subgroup of wheezy infants). FEF(75%) values tended to decrease at Ptrans values > 25 cm H2O. At Ptrans values between 20 and 25 cm H2O, most outcome variables are pressure independent. This range is therefore the most suitable for use with the raised-volume forced expiration technique.
Keyword Lung volumes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 17 Nov 2010, 11:29:56 EST