Using low-frequency oscillation to detect bronchodilator responsiveness in infants

Hayden, M.J., Petak, F., Hantos, Z., Hall, G. and Sly, P.D. (1998) Using low-frequency oscillation to detect bronchodilator responsiveness in infants. American Journal of Respiratory and Critical Care Medicine, 157 2: 574-579.

Author Hayden, M.J.
Petak, F.
Hantos, Z.
Hall, G.
Sly, P.D.
Title Using low-frequency oscillation to detect bronchodilator responsiveness in infants
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1073-449X
1535-4970
Publication date 1998-02-01
Sub-type Article (original research)
Volume 157
Issue 2
Start page 574
End page 579
Total pages 6
Place of publication New York, NY, United States
Publisher American Thoracic Society
Language eng
Abstract The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H20 during a brief Hering-Breuer reflex- induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (law), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 μg of salbutamol via a small- volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13% for the entire group) occurred following treatment with salbutamol (p < 0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65% ± 5.49%) and those with recurrent wheeze (17.58% ± 8.67%). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in law or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants.
Keyword Wheezy infants
Respiratory mechanics
Airway obstruction
Cystic fibrosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 21:29:51 EST