The route of antigen delivery determines the airway and lung tissue mechanical responses in allergic rats

Hall, G.L., Petak, F., McMenamin, C. and Sly, P.D. (1999) The route of antigen delivery determines the airway and lung tissue mechanical responses in allergic rats. Clinical And Experimental Allergy, 29 4: 562-568. doi:10.1046/j.1365-2222.1999.00471.x


Author Hall, G.L.
Petak, F.
McMenamin, C.
Sly, P.D.
Title The route of antigen delivery determines the airway and lung tissue mechanical responses in allergic rats
Journal name Clinical And Experimental Allergy   Check publisher's open access policy
ISSN 0954-7894
1365-2222
Publication date 1999-04
Sub-type Article (original research)
DOI 10.1046/j.1365-2222.1999.00471.x
Volume 29
Issue 4
Start page 562
End page 568
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Background:
Previous results have shown tissue constriction in allergic animals following inhalation of an antigen. Further studies have demonstrated a differing response pattern in airway and parenchymal mechanics following inhaled (i.h.) or intravenous (i.v.) delivery of methacholine (MCh).

Objective:

The purpose of this study was to compare the acute allergic response in airway and parenchymal mechanics following i.h. and i.v. antigen challenge.

Methods:
Brown Norway rats were sensitized to ovalbumin (OVA). Rats were anaesthetized, paralysed, and thoracotomized, and lung input impedance (ZL) between 0.5 and 21 Hz was measured using small-amplitude pseudo-random oscillations at control, after saline, and for up to 1 h after either i.h. (n = 7) or i.v. (n = 5) administration of OVA. ZL was evaluated in terms of airway resistance (Raw) and inertante (law), and a constant phase tissue parenchymal damping (G) and elastance (H).

Results:
Following i.h. OVA challenge elevations were found in Raw [192 ± 32 (SE)%], G (223 ± 21%), and H (141 ± 5%). Raw showed higher elevation after i.v. challenge (418 ± 57%), whereas the elevation in G (278 ± 30%) and H (130 ± 4%) was approximately equal to those seen following inhalation of an antigen.

Conclusions:
Delivery (i.v.) of an antigen produces a significantly higher response in airway resistance, whereas inhaled antigen results in a mixed airway and parenchymal response.
Keyword Airway mechanics
Pulmonary mechanics
Forced oscillations
Acute allergic response
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:29:10 EST