Prevention of methacholine-induced changes in respiratory mechanics in piglets: a comparison of sevoflurane and halothane

Habre, Walid, Wildhaber, Johannes H. and Sly, Peter D. (1997) Prevention of methacholine-induced changes in respiratory mechanics in piglets: a comparison of sevoflurane and halothane. Anesthesiology, 87 3: 585-590. doi:10.1097/00000542-199709000-00019


Author Habre, Walid
Wildhaber, Johannes H.
Sly, Peter D.
Title Prevention of methacholine-induced changes in respiratory mechanics in piglets: a comparison of sevoflurane and halothane
Journal name Anesthesiology   Check publisher's open access policy
ISSN 0003-3022
1528-1175
Publication date 1997-09
Sub-type Article (original research)
DOI 10.1097/00000542-199709000-00019
Volume 87
Issue 3
Start page 585
End page 590
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Background: Sevoflurane is a new volatile anesthetic agent that may be a useful alternative to halothane for anesthesia in children. However, there is insufficient information about its effects on respiratory mechanics, particularly in the presence of constrictor stimuli.
Methods: Eighteen piglets had anesthesia induced and maintained with either pentobarbital (control: n = 8), 1 minimum alveolar concentration (MAC) sevoflurane (sevo: n = 5), or 1 MAC halothane (halo: n = 5). Pressure, flow, and volume were measured at the airway opening and used to calculate lung compliance (CL) and resistance (RL). Resistance was partitioned into airway (Raw) and parenchymal (Vti) components using alveolar pressure. Methacholine was infused intravenously in a dose sufficient (15 micro gram [center dot] kg sup -1 [center dot] h sup -1) to approximately double RL.
Results: The increase in RL seen in the control group was almost entirely due to an increase in Vti. Sevoflurane and halothane prevented the increase in RL and Vti (both P < 0.02) and the decrease in CL (both P < 0.02).
Conclusions: Sevoflurane and halothane can prevent methacholine-induced changes in lung function.
Keyword Anesthetics, inhalation: halothane; sevoflurane
Animal models
Lung function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:28:22 EST