Propofol or halothane anaesthesia for children with asthma: Effects on respiratory mechanics

Habre, W., Matsumoto, I. and Sly, P.D. (1996) Propofol or halothane anaesthesia for children with asthma: Effects on respiratory mechanics. British Journal of Anaesthesia, 77 6: 739-743.

Author Habre, W.
Matsumoto, I.
Sly, P.D.
Title Propofol or halothane anaesthesia for children with asthma: Effects on respiratory mechanics
Journal name British Journal of Anaesthesia   Check publisher's open access policy
ISSN 0007-0912
Publication date 1996-12
Sub-type Article (original research)
Volume 77
Issue 6
Start page 739
End page 743
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Propofol may cause histamine release and alter airway tone and reactivity. Although its use has been reported to be safe in asthmatics, there is a lack of information on its effect on lung function in children with asthma. We measured respiratory mechanics after i.v. or inhalation anaesthesia in 60 children, aged 2-12 yr, with or without asthma. Anaesthesia was induced with propofol 3 mg kg-1, fentanyl 1 μg kg-1 and atracurium 0.5 mg kg-1 and maintained with an infusion of propofol 10 mg kg-1 h-1 and 50% nitrous oxide in oxygen. Halothane was administered subsequently at a concentration of 1 MAC. Respiratory mechanics were measured by applying a single-compartment model using multi-linear regression analysis to calculate dynamic compliance (Crs,dyn) and respiratory system resistance (Rrs), based on: Pao V/Crs,dyn + V̇ Rrs + PA,EE, where Pao = airway opening pressure, PA,EE = alveolar pressure, V = volume and V= flow. The two groups were comparable in age, weight and ventilation variables (tidal volume and peak pressure). Respiratory mechanics during propofol anaesthesia were comparable in normal and asthmatic children (Rrs = 20.5 x 10-4 (SD 5.2 x 10-4) vs 21.5 x 10-4 (5.7 x 10-4) kPa ml-1 s-1 (ns) and Crs,dyn = 247.5 (76.5) vs 235.1 (63.8) ml kPa-1 (ns)). Halothane produced a minimal decrease in Rrs and a minimal increase in tidal volume in both groups without changes in Crs,dyn. In conclusion, respiratory mechanics were comparable propofol anaesthesia in both children with and without asthma. Changes in Rrs after halothane administration were not clinically relevant.
Keyword Anaesthesia, paediatric
Anaesthetics iv, propofol
Anaesthetics volatile, halothane
Ventilation, mechanics
Lung, mechanics
Lung, function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 17 Nov 2010, 11:27:58 EST