Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis

Douglas, T. A., Brennan, S., Gard, S., Berry, L., Gangell, C., Stick, S. M., Clements, B. S. and Sly, P. D. (2009) Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis. European Respiratory Journal, 33 2: 305-311. doi:10.1183/09031936.00043108


Author Douglas, T. A.
Brennan, S.
Gard, S.
Berry, L.
Gangell, C.
Stick, S. M.
Clements, B. S.
Sly, P. D.
Title Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis
Formatted title
Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
1399-3003
Publication date 2009-02
Year available 2008
Sub-type Article (original research)
DOI 10.1183/09031936.00043108
Volume 33
Issue 2
Start page 305
End page 311
Total pages 7
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Formatted abstract
When do infants and young children with cystic fibrosis acquire infection with Pseudomonas aeruginosa? Can this be eradicated when first detected?
Children <6 yrs of age participated in an annual bronchoalveolar lavage (BAL)-based microbiological surveillance programme in Perth, Australia. When P. aeruginosa was detected, an eradication programme using combination treatment with i.v., oral and nebulised antibiotics was undertaken. Repeat BAL was performed 3 months following treatment, to assess eradication success.
P. aeruginosa was detected in 33 (28.4%) children; median (range) age at detection was 30.5 (3.3-71.4) months. P. aeruginosa was mucoid at detection in six (18.2%) out of 33 patients and associated with respiratory symptoms in 16 (48.5%) out of 33 children. In total, 26 children underwent eradication therapy, with P. aeruginosa eradicated in 20 (77%) out of 26 following one eradication cycle and in three (total 88%) additional children following a second cycle. Eradication was associated with a significant decrease in neutrophil elastase and interleukin-1β in BAL fluid 12 months post eradication.
Eradication of Pseudomonas aeruginosa infection is achievable in young children with cystic fibrosis for up to 5 yrs using combination i.v., oral and nebulised antibiotic therapy and is associated with reduced pulmonary inflammation 12 months post eradication.
Keyword Bronchoalveolar lavage
Children
Cystic fibrosis
Eradication
Microbiological surveillance
Pseudomonas aeruginosa
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online before print November 14, 2008

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 73 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 73 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 17 Nov 2010, 11:23:56 EST