Atypical mycobacterial pulmonary disease and bronchial obstruction in HIV-negative children

Dore, N.D., LeSouef, P.N., Masters, B., Francis, P.W., Cooper, D.M., Wildhaber, J.H., Fall, A.J. and Sly, P.D. (1998) Atypical mycobacterial pulmonary disease and bronchial obstruction in HIV-negative children. Pediatric Pulmonology, 26 6: 380-388. doi:10.1002/(SICI)1099-0496(199812)26:6<380::AID-PPUL2>3.0.CO;2-I


Author Dore, N.D.
LeSouef, P.N.
Masters, B.
Francis, P.W.
Cooper, D.M.
Wildhaber, J.H.
Fall, A.J.
Sly, P.D.
Title Atypical mycobacterial pulmonary disease and bronchial obstruction in HIV-negative children
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
1099-0496
Publication date 1998-12
Sub-type Article (original research)
DOI 10.1002/(SICI)1099-0496(199812)26:6<380::AID-PPUL2>3.0.CO;2-I
Volume 26
Issue 6
Start page 380
End page 388
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Atypical mycobacterial infection in HIV-negative children usually presents with cervical lymphadenopathy. We report on 10 children who are HIV- negative and who presented with pulmonary disease, in whom either culture- proven atypical mycobacterium infection (four), positive avian Mantoux test (five), or lack of response to human tuberculosis treatment (one) had been observed. One case was subsequently diagnosed as chronic granulomatous disease and illustrates that children with atypical mycobacterial pulmonary infection should have their immune status fully investigated. Bronchial obstruction was observed in eight cases, and of these, endobronchial disease was found in six children. The diagnosis of atypical mycobacterial disease is difficult, and a negative avian Mantoux test does not exclude the diagnosis. The availability of clarithromycin and rifabutin has offered new therapeutic options in treating atypical mycobacterial pulmonary infection, but management of these cases can be prolonged and difficult.
Keyword Atypical mycobacteria
Pulmonary disease
Endobronchitis
Bronchial obstruction
Chronic granulomatous disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:23:44 EST