Intestinal helminth infestation is associated with increased bronchial responsiveness in children

da Silva, Emerson R., Sly, Peter D., de Pereira, Marilyn U., Pinto, Leonardo A., Jones, Marcus H., Pitrez, Paulo M. and Stein, Renato T. (2008) Intestinal helminth infestation is associated with increased bronchial responsiveness in children. Pediatric Pulmonology, 43 7: 662-665. doi:10.1002/ppul.20833


Author da Silva, Emerson R.
Sly, Peter D.
de Pereira, Marilyn U.
Pinto, Leonardo A.
Jones, Marcus H.
Pitrez, Paulo M.
Stein, Renato T.
Title Intestinal helminth infestation is associated with increased bronchial responsiveness in children
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
1099-0496
Publication date 2008-07-01
Sub-type Article (original research)
DOI 10.1002/ppul.20833
Volume 43
Issue 7
Start page 662
End page 665
Total pages 4
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Non-atopic asthma is the predominant phenotype in non-affluent parts of Latin America. We recently reported that infestation with Ascaris lumbricoides increased the risk of non-atopic asthma in less affluent areas of Brazil but the mechanism is unclear. The present study was conducted to determine whether helminth infestation is associated with heightened bronchial responsiveness (BHR), a common finding in asthma. A random sample of 50 asthmatic and 50 non-asthmatic controls (mean age 10.1 years) were selected from a larger cohort (n = 1,011) without knowledge of their helminth infestation status. Three stool samples were collected from each child on different days and each sample was analyzed by the Kato-Katz method for quantitative determination of helminth eggs. Bronchial provocation tests were performed with inhaled 4.5% hypertonic saline using the ISAAC Phase II standardized protocol. There was no difference between the prevalence of positive BHR in the asthmatics (20.4%) compared with the controls (14.6%) (P=1.0). Helminth infestation was detected in 24.0% of children, with A. lumbricoides being the most common. Children with high load infestation (≥100 eggs/g) were five times more likely to have BHR than children with low load or no infestation. Despite the small sample size the results of the present study suggest that the link between high load helminth infestation and non-atopic asthma may be mediated via heightened bronchial responsiveness, possibly due to an inflammatory response to the pulmonary phase of the helminth life cycle.
Keyword asthma
helminthes
bronchial hyperresponsiveness
children
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 21:23:10 EST