In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D

Collins, R. A., Ikegami, M., Korfhagen, T. R., Whitsett, J. A. and Sly, P. D. (2003) In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D. Pediatric Research, 53 3: 463-467. doi:10.1203/01.PDR.0000049464.46191.BF


Author Collins, R. A.
Ikegami, M.
Korfhagen, T. R.
Whitsett, J. A.
Sly, P. D.
Title In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
1530-0447
Publication date 2003-03
Sub-type Article (original research)
DOI 10.1203/01.PDR.0000049464.46191.BF
Volume 53
Issue 3
Start page 463
End page 467
Total pages 5
Place of publication New York, NY, United States
Publisher Nature
Language eng
Formatted abstract
Mice deficient in surfactant protein D [SP-D (-/-)] develop progressive emphysema with age, associated with loss of parenchymal tissue, subpleural fibrosis, and accumulation of abnormal elastin fibers. We measured the changes in lung function, partitioned into components for the airways and lung parenchyma, occurring with age in SP-D (-/-) mice at three ages (n = 8 per group) (5, 8, and 13 wk). Impedance spectra between 0.25 and 19.625 Hz were calculated and a model, consisting of an airway compartment [airway resistance (Raw) and inertance (Iaw)] and a constant-phase tissue compartment [coefficients of tissue damping (G) and elastance (H)], was fitted to the data. Hysteresivity was calculated as G/H. Adult values of Raw, G, and H are reached by 8 wk of age in wild-type controls. Raw and H were lower at all ages in SP-D (-/-) compared with the wild-type controls (p = 0.006 and 0.029, respectively), and a similar trend was seen in G (p = 0.060). The patterns of change in respiratory mechanics were similar in both SP-D (+/+) and (-/-) groups. There were no changes in hysteresivity with age and no differences between wild-type and SP-D (-/-) mice. These data demonstrate that the changes in lung structure in SP-D (-/-) mice are reflected in the mechanical properties of both airway and lung parenchyma measured in vivo.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 11:22:41 EST