Lack of long-term effects of respiratory syncytial virus infection on airway function in mice

Collins, Rachel A., Gualano, Rosa C., Zosky, Graeme R., Chiappetta, Constance L., Turner, Debra J., Colasurdo, Giuseppe N., Hantos, Zoltan and Sly, Peter D. (2007) Lack of long-term effects of respiratory syncytial virus infection on airway function in mice. Respiratory Physiology & Neurobiology, 156 3: 345-352. doi:10.1016/j.resp.2006.11.009


Author Collins, Rachel A.
Gualano, Rosa C.
Zosky, Graeme R.
Chiappetta, Constance L.
Turner, Debra J.
Colasurdo, Giuseppe N.
Hantos, Zoltan
Sly, Peter D.
Title Lack of long-term effects of respiratory syncytial virus infection on airway function in mice
Journal name Respiratory Physiology & Neurobiology   Check publisher's open access policy
ISSN 1569-9048
1878-1519
Publication date 2007-06-01
Sub-type Article (original research)
DOI 10.1016/j.resp.2006.11.009
Volume 156
Issue 3
Start page 345
End page 352
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Epidemiological data suggests lower respiratory infections (LRI) with respiratory syncytial virus (RSV) are capable of causing long-term abnormalities in airway function. To directly test the effects of RSV LRI, we infected adult and weanling BALB/c mice with RSV (A2) or vehicle. Respiratory system impedance was used to assess baseline airway function and responses to iv methacholine (MCh) at 4, 8, 24 and 34 weeks post infection. In vitro airway responses were measured 24 weeks post infection using electrical field stimulation and MCh. Mice infected as adults showed no alterations in airway function. Mice infected as weanlings had increased MCh responses 24 weeks post infection. However, the increased response was not present 34 weeks post infection nor accompanied by alterations in in vitro responses or airway morphometry. This study did not detect long-lasting changes in airway function following RSV infection in mice. These data do not provide support for alterations in airway structure or function being responsible for the observed relationship between RSV infection in infants and asthma in later life.
Keyword forced oscillation
airway resistance
airway hyperresponsiveness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 17 Nov 2010, 21:22:31 EST