Association between lower respiratory tract symptoms and falls in peak expiratory flow in children

Clough, J.B. and Sly, P.D. (1995) Association between lower respiratory tract symptoms and falls in peak expiratory flow in children. European Respiratory Journal, 8 5: 718-722. doi:10.1183/09031936.95.08050718

Author Clough, J.B.
Sly, P.D.
Title Association between lower respiratory tract symptoms and falls in peak expiratory flow in children
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 1995-05
Sub-type Article (original research)
DOI 10.1183/09031936.95.08050718
Volume 8
Issue 5
Start page 718
End page 722
Total pages 5
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Abstract Peak expiratory flow (PEF) measurements are increasingly recommended in childhood asthma management. However, few data are available on the temporal relationship between the onset of upper and lower respiratory tract symptoms and significant falls in PEF. We wanted to determine whether falls in PEF constitute a sensitive marker for clinical episodes of respiratory morbidity. We therefore analysed data on daily PEF and respiratory symptom recording from a 12 month longitudinal study in 192 children aged 7 and 8 yrs with current respiratory symptoms. Outcome measures were number of and relationship between: 1) episodes of fall in PEF (defined as a fall in PEF for more than 2 days to <1.5 SD below individual mean morning PEF); and 2) upper and lower respiratory tract symptom events (defined as a respiratory symptom score of >3 units within three consecutive days). One hundred and eighty six of the 192 children completed the study. For the group as a whole, the mean number of PEF episodes per subject was 3.5, and the mean number of symptom events 8.9, with 29% of symptom events being temporally associated with a PEF episode, and 40% of PEF episodes not being accompanied by a symptom event. Forty nine percent of PEF episodes were preceded by at least two consecutive days of either upper or lower respiratory symptoms. We conclude that falls in PEF alone were not a sensitive marker for episodes of respiratory morbidity. On almost half of the occasions where PEF did fall, morbidity could have been detected at least 2 days earlier using symptom reporting. A combination of PEF measurement and symptom reporting should be used to identify exacerbations of asthma morbidity in children.
Keyword Asthma
Peak expiratory flows
Bronchial responsiveness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 17 Nov 2010, 11:22:21 EST