The influence of age on aerosol deposition in children with cystic fibrosis

Chua, H.L., Collis, G.G., Newbury, A.M., Chan, K., Bower, G.D., Sly, P.D. and Le Souef, P.N. (1994) The influence of age on aerosol deposition in children with cystic fibrosis. European Respiratory Journal, 7 12: 2185-2191. doi:10.1183/09031936.94.07122185

Author Chua, H.L.
Collis, G.G.
Newbury, A.M.
Chan, K.
Bower, G.D.
Sly, P.D.
Le Souef, P.N.
Title The influence of age on aerosol deposition in children with cystic fibrosis
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 1994-12
Sub-type Article (original research)
DOI 10.1183/09031936.94.07122185
Volume 7
Issue 12
Start page 2185
End page 2191
Total pages 7
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Formatted abstract
Nebulized aerosols are commonly used to deliver drugs for the treatment of respiratory disease in children, but there are inadequate data on the dose of drug depositing in the lungs in this age group, and the effect of age on this dose. We therefore aimed to quantify total and regional deposition of nebulized aerosol in children of widely differing age. Twelve infants (median age 0.8 yrs, range 0.3-1.4 yrs) who were asleep, and eight older children (median age 10.8 yrs, range 6.3-18.0 yrs) with cystic fibrosis were studied. Radiolabelled normal saline aerosol was generated by a Turret nebolizer, with a driving now of 9 l min-1 . All subjects inhaled aerosol via the nasal route, whilst the older children undertook a second study with inhalation via the oral route. Following aerosol inhalation, planar and single-photon emission computed tomography (SPECT) scans were obtained. For the nasal route, total lung deposition was lower in infants (median 1.3%, range 0.3-1.6%) than in older children (median 2.7%, range 1.6-4.4%). For the older children inhaling via the nasal or oral route, there was no influence of age on lung, upper respiratory tract, or the sum of upper respiratory tract and lung deposition. We conclude that the dose of a nasally inspired aerosol reaching the longs of infants who are asleep is approximately half that for older children, when the nebulizer is operating at 9 l min -1. Age does not affect deposition of nasally or orally inspired aerosols in older children.
Keyword Aerosol deposition
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 17 Nov 2010, 11:22:09 EST