Impact of supplemental oxygen in mechanically ventilated adult and infant mice

Cannizzaro, Vincenzo, Berry, Luke J., Zosky, Graeme R., Turner, Debra J., Hantos, Zoltan and Sly, Peter D. (2009) Impact of supplemental oxygen in mechanically ventilated adult and infant mice. Respiratory Physiology & Neurobiology, 165 1: 61-66. doi:10.1016/j.resp.2008.10.006

Author Cannizzaro, Vincenzo
Berry, Luke J.
Zosky, Graeme R.
Turner, Debra J.
Hantos, Zoltan
Sly, Peter D.
Title Impact of supplemental oxygen in mechanically ventilated adult and infant mice
Journal name Respiratory Physiology & Neurobiology   Check publisher's open access policy
ISSN 1569-9048
Publication date 2009-01
Sub-type Article (original research)
DOI 10.1016/j.resp.2008.10.006
Volume 165
Issue 1
Start page 61
End page 66
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The aim of the present study was to determine the short-term effects of hyperoxia on respiratory mechanics in mechanically ventilated infant and adult mice. Eight and two week old BALB/c mice were exposed to inspired oxygen fractions (FIO2) of 0.21, 0.3, 0.6, and 1.0, respectively, during 120 min of mechanical ventilation. Respiratory system mechanics and inflammatory responses were measured. Using the low-frequency forced oscillation technique no differences were found in airway resistance between different FIO2 groups when corrected for changes in gas viscosity. Coefficients of lung tissue damping and elastance were not different between groups and showed similar changes over time in both age groups. Inflammatory responses did not differ between groups at either age. Hyperoxia had no impact on respiratory mechanics during mechanical ventilation with low tidal volume and positive end-expiratory pressure. Hence, supplemental oxygen can safely be applied during short-term mechanical ventilation strategies in infant and adult mice.
Keyword Hyperoxia
Hyperoxia-induced lung injury
Infant mouse model
Respiratory system mechanics
Airway smooth muscle tone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Nov 2010, 11:21:31 EST