Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice

Cannizzaro, Vincenzo, Berry, Luke J., Nicholls, Phillip K., Zosky, Graeme R., Turner, Debra J., Hantos, Zoltan and Sly, Peter D. (2009) Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice. Respiratory Physiology & Neurobiology, 169 3: 243-251. doi:10.1016/j.resp.2009.09.012


Author Cannizzaro, Vincenzo
Berry, Luke J.
Nicholls, Phillip K.
Zosky, Graeme R.
Turner, Debra J.
Hantos, Zoltan
Sly, Peter D.
Title Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice
Journal name Respiratory Physiology & Neurobiology   Check publisher's open access policy
ISSN 1569-9048
1878-1519
Publication date 2009-12
Sub-type Article (original research)
DOI 10.1016/j.resp.2009.09.012
Volume 169
Issue 3
Start page 243
End page 251
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH2O and volume- (20 or 40 mL/kg) or pressure-controlled (25 cmH2O) RMs every 5 or 75 min for 150 min. The low-frequency forced oscillation technique was used to measure respiratory input impedance. Large RMs resulting in peak airway opening pressures (Pao) > 30 cmH2O did not increase inflammatory response or affect transcutaneous oxygen saturation but significantly lowered airway resistance, tissue damping and tissue elastance; the latter changes are likely associated with the bimodal pressure–volume behavior observed in mice. PEEP increase alone and application of RMs producing peak Pao below 25 cmH2O did not prevent or reverse changes in lung mechanics; whereas frequent application of substantial RMs on top of elevated PEEP levels produced stable lung mechanics without signs of lung injury.
Keyword Pulmonary elastance
Airway resistance
Lung volume history
Recruitment maneuver
Mechanical ventilation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 11:21:20 EST