Developmental changes in airway and tissue mechanics in mice

Bozanich, Elizabeth M., Collins, Rachel A., Thamrin, Cindy, Hantos, Zoltan, Sly, Peter D. and Turner, Debra J. (2005) Developmental changes in airway and tissue mechanics in mice. Journal of Applied Physiology, 99 1: 108-113. doi:10.1152/japplphysiol.01111.2004

Author Bozanich, Elizabeth M.
Collins, Rachel A.
Thamrin, Cindy
Hantos, Zoltan
Sly, Peter D.
Turner, Debra J.
Title Developmental changes in airway and tissue mechanics in mice
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 2005-07
Sub-type Article (original research)
DOI 10.1152/japplphysiol.01111.2004
Volume 99
Issue 1
Start page 108
End page 113
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract Most studies using mice to model human lung diseases are carried out in adults, although there is emerging interest in the effects of allergen, bacterial, and viral exposure early in life. This study aims to characterize lung function in BALB/c mice from infancy (2 wk) through to adulthood (8 wk). The low-frequency forced oscillation technique was used to obtain impedance data, partitioned into components representing airway resistance, tissue damping, tissue elastance, and hysteresivity (tissue damping/tissue elastance). Measurements were made at end-expiratory pause (transrespiratory system pressure = 2 cmH2O) and during relaxed slow expiration from 20 to 0 cmH2O. Airway resistance decreased with age from 0.63 cmH2O·ml–1·s at 2 wk to 0.24 cmH2O·ml–1·s at 8 wk (P < 0.001). Both tissue damping and tissue elastance decreased with age (P < 0.001) from 2 to 5 wk, then plateaued through to 8 wk (P < 0.001). This pattern was seen both in measurements taken at end-expiratory pause and during expiration. There were no age-related changes seen in hysteresivity when measured at end-expiratory pause, but the pattern of volume dependence did differ with the age of the mice. These changes in respiratory mechanics parallel the reported structural changes of the murine lung from the postnatal period into adulthood.
Keyword lung mechanics
forced oscillations
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Created: Wed, 17 Nov 2010, 11:18:43 EST