Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children

Belshe, Robert B., Newman, Frances K., Anderson, Edwin L., Wright, Peter F., Karron, Ruth A., Tollefson, Sharon, Henderson, Frederick W., Meissner, H. Cody, Madhi, Shabir, Roberton, Don, Marshall, Helen, Loh, Richard, Sly, Peter, Murphy, Brian, Tatem, Joanne M., Randolph, Valerie, Hackell, Jill, Gruber, William and Tsai, Theodore F. (2004) Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children. Journal of Infectious Diseases, 190 12: 2096-2103. doi:10.1086/425981


Author Belshe, Robert B.
Newman, Frances K.
Anderson, Edwin L.
Wright, Peter F.
Karron, Ruth A.
Tollefson, Sharon
Henderson, Frederick W.
Meissner, H. Cody
Madhi, Shabir
Roberton, Don
Marshall, Helen
Loh, Richard
Sly, Peter
Murphy, Brian
Tatem, Joanne M.
Randolph, Valerie
Hackell, Jill
Gruber, William
Tsai, Theodore F.
Title Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2004-12
Sub-type Article (original research)
DOI 10.1086/425981
Volume 190
Issue 12
Start page 2096
End page 2103
Total pages 8
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Formatted abstract
We evaluated a combination respiratory syncytial virus (RSV) and parainfluenza 3 virus (PIV3) live, attenuated intranasal vaccine for safety, viral replication, and immunogenicity in doubly seronegative children 6–18 months old. RSV cpts-248/404 and PIV3-cp45 vaccines were combined in a dose of 105 plaque-forming units of each per 0.5-mL dose and compared with monovalent vaccines or placebo. The virus shedding pattern of RSV was not different between monovalent RSV cpts-248/404 vaccine and combination vaccine. Modest reductions in the shedding of PIV3-cp45 vaccine virus were found after the administration of RSV cpts-248/404 and PIV3-cp45 vaccine, relative to monovalent PIV3 vaccine; 16 (76%) of 21 children given combination vaccine shed PIV3- cp45 versus 11 (92%) of 12 of those given monovalent PIV3 vaccine. Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/ PV3 vaccine is feasible for simultaneous administration, and further studies are warranted.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 11:18:03 EST