Parental smoking impairs vaccine responses in children with atopic genotypes

Baynam, Gareth, Khoo, Siew-Kim, Rowe, Julie, Zhang, Guicheng, Laing, Ingrid, Hayden, Catherine, Kusel, Merci, DeKlerk, Nick, Sly, Peter, Goldblatt, Jack, Holt, Patrick and LeSouef, Peter (2007) Parental smoking impairs vaccine responses in children with atopic genotypes. Journal of Allergy And Clinical Immunology, 119 2: 366-374. doi:10.1016/j.jaci.2006.09.018

Author Baynam, Gareth
Khoo, Siew-Kim
Rowe, Julie
Zhang, Guicheng
Laing, Ingrid
Hayden, Catherine
Kusel, Merci
DeKlerk, Nick
Sly, Peter
Goldblatt, Jack
Holt, Patrick
LeSouef, Peter
Title Parental smoking impairs vaccine responses in children with atopic genotypes
Journal name Journal of Allergy And Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2007-02
Sub-type Article (original research)
DOI 10.1016/j.jaci.2006.09.018
Volume 119
Issue 2
Start page 366
End page 374
Total pages 9
Place of publication Milwaukee, United States
Publisher Mosby
Language eng
Abstract Background Gene-environment interactions play central roles in controlling postnatal maturation of immune function, but their effects on infant vaccine responses are unknown. Genetic variants associated with atopy and the environmental factor of exposure to parental smoking (PS) of tobacco independently alter immune responses. Objective We sought to investigate the hypothesis that genetic variants associated with atopy and their interaction with PS influence infant vaccine responsiveness. Methods In 200 infants with parental atopic history, relationships were sought between polymorphisms in the IL-4, IL-4 receptor ɑ (IL-4Rɑ), and IL-13 genes; PS; and immune responses to diphtheria/tetanus vaccination. Results Analyses stratified by PS unmasked negative associations between atopic alleles of these genes and vaccine outcomes. The most consistent involved the IL-4Rɑ 551 QR/QQ genotypes, which were associated with reduced IgG levels (P = .02) and T-cell responses (IFN-ɣ, P = .002; IL-10, P = .01; 1L-13, P = .01; IL-5, P = .06) to tetanus toxoid and parallel reductions in polyclonal T-cell responses and innate immune responses in PS-exposed infants. Conclusion PS potentiates suppressive effects of variants in immune response genes in children. These effects are not observed in the absence of this exposure. Ultimately, this finding might have implications for infant vaccination in countries with high smoking rates. It might also have broader implications in relation to environmental toxicology because it demonstrates specific mechanisms through which the developing immune system might be differentially sensitive to low-level toxicant exposures. Clinical implications PS interacts with genes associated with atopy to impair vaccine responses. These interactions might have vaccine design and public health implications.
Keyword genetics
environmental exposure
public health
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Nov 2010, 11:17:29 EST