Cytomegalovirus retinitis, Human Immunodeficiency virus antibody positivity and normal T helper cell numbers

Thomson, R.M., Conrad, D., Antoszewska, H., Croxson, M.C. and McCormack, J.G. (1998) Cytomegalovirus retinitis, Human Immunodeficiency virus antibody positivity and normal T helper cell numbers. Journal of Infection, 37 2: 186-188. doi:10.1016/S0163-4453(98)80176-X


Author Thomson, R.M.
Conrad, D.
Antoszewska, H.
Croxson, M.C.
McCormack, J.G.
Title Cytomegalovirus retinitis, Human Immunodeficiency virus antibody positivity and normal T helper cell numbers
Journal name Journal of Infection   Check publisher's open access policy
ISSN 0163-4453
1532-2742
Publication date 1998-09
Sub-type Article (original research)
DOI 10.1016/S0163-4453(98)80176-X
Volume 37
Issue 2
Start page 186
End page 188
Total pages 3
Publisher Elsevier
Language eng
Formatted abstract
We describe a 46-year-old man in whom retinitis was diagnosed as his initial HIV and AIDS defining illness. A diagnosis of CMV infection was made based on the clinical appearance of the fundus and confirmed by DNA polymerase chain reaction (PCR) on his vitreous biopsy. His CD4+ T lymphocyte count at the time was 580 x 106/l (16%) with a CD4:CD8 ration of 0.28. He had a splenectomy following trauma more than 20 years earlier. He responded very well to intravenous and oral ganciclovir and remains recurrence-free almost 2 years later. This case and others highlight two issues: (i) CMV retinitis in HIV positive patients is not confined to those with very low CD4+ T lymphocyte counts; (ii) previous splenectomy may have an impact on CD4+ cell numbers and function.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 16 Nov 2010, 21:46:41 EST by Dr Rachel Thomson on behalf of Medicine - Prince Charles Hospital