The effect of ageing on human lymphocyte subsets: comparison of males and females

Yan, Jun, Greer, Judith M., Hull, Renee, O'Sullivan, John D., Henderson, Robert D., Read, Stephen J. and McCombe, Pamela A. (2010) The effect of ageing on human lymphocyte subsets: comparison of males and females. Immunity & Ageing, 7 4: 1-10. doi:10.1186/1742-4933-7-4

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Author Yan, Jun
Greer, Judith M.
Hull, Renee
O'Sullivan, John D.
Henderson, Robert D.
Read, Stephen J.
McCombe, Pamela A.
Title The effect of ageing on human lymphocyte subsets: comparison of males and females
Journal name Immunity & Ageing   Check publisher's open access policy
ISSN 1742-4933
Publication date 2010-03-16
Sub-type Article (original research)
DOI 10.1186/1742-4933-7-4
Open Access Status DOI
Volume 7
Issue 4
Start page 1
End page 10
Total pages 10
Place of publication London, England, U.K.
Publisher BioMed Central
Collection year 2011
Language eng
Formatted abstract
There is reported to be a decline in immune function and an alteration in the frequency of circulating lymphocytes with advancing age. There are also differences in ageing and lifespan between males and females. We performed this study to see if there were differences between males and females in the frequency of the different lymphocyte subsets with age.

Using flow cytometry we have examined different populations of peripheral blood leukocytes purified from healthy subjects with age ranging from the third to the tenth decade. We used linear regression analysis to determine if there is a linear relationship between age and cell frequencies. For the whole group, we find that with age there is a significant decline in the percentage of naïve T cells and CD8+ T cells, and an increase in the percentage of effector memory cells, CD4+foxp3+ T cells and NK cells. For all cells where there was an effect of ageing, the slope of the curve was greater for men than for women and this was statistically significant for CD8+αβ+ T cells and CD3+CD45RA-CCR7- effector memory cells. There was also a difference for naïve cells but this was not significant.

The cause of the change in percentage of lymphocyte subsets with age, and the different effects on males and females is not fully understood but warrants further study.
Keyword CD3 antigen
CD45RA antigen
chemokine receptor CCR7
transcription factor FOXP3
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 1742

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
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Citation counts: Scopus Citation Count Cited 45 times in Scopus Article | Citations
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Created: Tue, 16 Nov 2010, 14:02:50 EST by Judith M Greer on behalf of UQ Centre for Clinical Research