Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon

Cui Xiaoying, Pelekanos, Matthew, Burne, Thomas H.J., McGrath, John J. and Eyles, Darryl W. (2010) Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon. Neuroscience Letters, 486 3: 220-223. doi:10.1016/j.neulet.2010.09.057


Author Cui Xiaoying
Pelekanos, Matthew
Burne, Thomas H.J.
McGrath, John J.
Eyles, Darryl W.
Title Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 2010-12-17
Sub-type Article (original research)
DOI 10.1016/j.neulet.2010.09.057
Volume 486
Issue 3
Start page 220
End page 223
Total pages 4
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Collection year 2011
Language eng
Formatted abstract
Schizophrenia is a neurodevelopment disorder that is strongly associated with alterations in dopamine neurotransmission. Common features of animal models of schizophrenia include behavioural, cognitive and/or pharmacological abnormalities reflective of aberrant DA signaling. The aim of this study was to examine the expression of genes important for dopaminergic development and maturation within the embryonic mesencephalon using an epidemiologically-informed animal model of schizophrenia, the developmental vitamin D (DVD) deficient rat model. Two groups of female Sprague–Dawley rats were fed either a diet replete (1000 IU/kg) or deplete (0 IU/kg) of vitamin D, mated and foetal mesencephalon collected at embryonic day (E) E12 or E15. Using real time-PCR, the DVD-deficient embryos had a significant reduction in factors crucial in specifying dopaminergic phenotype, such as Nurr1 and p57Kip2. No group differences were found for Lmx1b or Ptx3. Reductions in these specification factors may alter the ontogeny of DA neurons and may ultimately help to explain the behavioural abnormalities reported in adult offspring from this model.
Keyword Vitamin D
Schizophrenia
Nurr1
p57Kip2
Dopamine ontogeny
Animal model
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 16 Nov 2010, 21:43:36 EST by Dr Thomas Burne on behalf of Queensland Brain Institute