Filtering of visual information in the tectum by an identified neural circuit

Del Bene, Filippo, Wyart, Claire, Robles, Estuardo, Scott, Ethan K., Isacoff, Ehud Y. and Baier, Herwig (2010) Filtering of visual information in the tectum by an identified neural circuit. Science, 330 6004: 669-673. doi:10.1126/science.1192949

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Author Del Bene, Filippo
Wyart, Claire
Robles, Estuardo
Scott, Ethan K.
Isacoff, Ehud Y.
Baier, Herwig
Title Filtering of visual information in the tectum by an identified neural circuit
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2010-10-29
Sub-type Article (original research)
DOI 10.1126/science.1192949
Volume 330
Issue 6004
Start page 669
End page 673
Total pages 5
Place of publication Washington, DC, U. S. A.
Publisher American Association for the Advancement of Science
Collection year 2011
Language eng
Formatted abstract
The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter γ-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with KillerRed, or silencing of their synaptic transmission, eliminates the size tuning of deeper layers and impairs the capture of prey.
Keyword Zebrafish optic tectum
Superior colliculus
Larval zebrafish
In-vivo
Enhancer
Cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes accepted 17 September 2010 - 10.1126/science.1192949. -- Publication title. Title supplied author (prepublication?) Functional identification of the neural substrate for tectum visual selectivity

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 86 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 16 Nov 2010, 10:10:00 EST by Dr Ethan Scott on behalf of School of Biomedical Sciences