Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis

Wilke, Diego Veras, Jimenez, Paula Christine, Araújo, Renata Mendonça, da Silva, Wildson Max Barbosa, Pessoa, Otília Deusdênia Loiola, Silveira, Edilberto Roch, Pessoa, Claudia, de Moraes, Manoel Odorico, Skwarczynski, Mariusz, Simerska, Paul, Toth, Istvan and Costa-Lotufo, Letícia Veras (2010) Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis. Bioorganic and Medicinal Chemistry, 18 22: 7997-8004. doi:10.1016/j.bmc.2010.09.027

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ220437.pdf HERDC Checklist - not publicly available application/pdf 48.22KB 2

Author Wilke, Diego Veras
Jimenez, Paula Christine
Araújo, Renata Mendonça
da Silva, Wildson Max Barbosa
Pessoa, Otília Deusdênia Loiola
Silveira, Edilberto Roch
Pessoa, Claudia
de Moraes, Manoel Odorico
Skwarczynski, Mariusz
Simerska, Paul
Toth, Istvan
Costa-Lotufo, Letícia Veras
Title Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis
Journal name Bioorganic and Medicinal Chemistry   Check publisher's open access policy
ISSN 0968-0896
Publication date 2010-11-15
Sub-type Article (original research)
DOI 10.1016/j.bmc.2010.09.027
Volume 18
Issue 22
Start page 7997
End page 8004
Total pages 8
Editor Dirk Trauner
Place of publication Oxford, U.K.
Publisher Pergamon/Elsevier
Collection year 2011
Language eng
Formatted abstract
Lipidic α-amino acids (LAAs) have been described as non-natural amino acids with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we have obtained a mixture of two cytotoxic LAAs (1a and 1b) from the zoanthid Protopalythoa variabilis. The anti-proliferative potential of 14 synthetic LAAs and 1a/1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, and HL-60). Five of the synthetic LAAs showed high percentage of tumor cell inhibition, while 1a/1b completely inhibited tumor cell growth. Additionally, apoptotic effects of 1a/1b were studied on HL-60 cell line. 1a/1b-treated cells showed apoptosis morphology, loss of mitochondrial potential, and DNA fragmentation.
© 2010 Elsevier Ltd. All rights reserved.
Keyword Apoptosis
Lipidic α-amino acids
Protopalythoa variabilis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Issue title: Chemical Neurobiology, edited by Dirk Trauner

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 15 Nov 2010, 22:19:21 EST by Dr Mariusz Skwarczynski on behalf of School of Chemistry & Molecular Biosciences