Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design

Zaman, Mehfuz, Skwarczynski, Marius and Toth, Istvan (2010). Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design. In Lorraine C. Welles (Ed.), Dendritic Cells: Types, Life Cycles and Biological Functions (pp. 63-80) New York, NY, U.S.A.: Nova Science Publishers.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ220433_fulltext_other.pdf HERDC combined - not publicly available application/pdf 13.33MB 4
uq220433_Checklists.pdf HERDC Checklist - Not publicly available application/pdf 178.90KB 2
Author Zaman, Mehfuz
Skwarczynski, Marius
Toth, Istvan
Title of chapter Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design
Title of book Dendritic Cells: Types, Life Cycles and Biological Functions
Place of Publication New York, NY, U.S.A.
Publisher Nova Science Publishers
Publication Year 2010
Sub-type Research book chapter (original research)
Series Cell Biology Research Progress
ISBN 9781616689544
1616689544
9781612090689
1612090680
Editor Lorraine C. Welles
Chapter number 3
Start page 63
End page 80
Total pages 18
Total chapters 11
Collection year 2011
Language eng
Formatted Abstract/Summary
Toll-like receptors (TLRs) which recognise pathogen associated molecular patterns (PAMPs) are a vital link between the innate and adaptive immunity. TLR-mediated activation of dendritic cells (DCs) is a crucial step in triggering adaptive immunity as DCs are the principal initiator and modulator of the immune response. With the advent of well-defined synthetic lipid moieties that structurally represent PAMPs, it is now possible to design synthetic vaccines containing disease-specific epitopes. This review provides a brief overview of why DCs represent a crucial target and tool for vaccination and TLR mediated DC activation efficiently stimulates immune responses. Particular emphasis is given to our recent understanding of the lipid component of various lipidated peptides (lipopeptides) targeting TLR2 mediated DC activation.
Copyright © 2010 by Nova Science Publishers, Inc.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 15 Nov 2010, 22:08:03 EST by Dr Mariusz Skwarczynski on behalf of School of Chemistry & Molecular Biosciences