Anti-MuSK-positive myasthenia gravis patient antibody causes aberrant activation of MuSK and disassembly of acetylcholine receptor clusters

Ghazanfari, N., Gervasio, O. L., Ngo, S. T., Reddel, S. R. and Phillips, W. D. (2009). Anti-MuSK-positive myasthenia gravis patient antibody causes aberrant activation of MuSK and disassembly of acetylcholine receptor clusters. In: , Proceedings of: Australian Neuroscience Society Annual Meeting 2009. ANS 2009: 29th Annual Meeting of the Australian Neuroscience Society, Canberra, ACT, Australia, (69-69). 27-30 January 2009.


Author Ghazanfari, N.
Gervasio, O. L.
Ngo, S. T.
Reddel, S. R.
Phillips, W. D.
Title of paper Anti-MuSK-positive myasthenia gravis patient antibody causes aberrant activation of MuSK and disassembly of acetylcholine receptor clusters
Conference name ANS 2009: 29th Annual Meeting of the Australian Neuroscience Society
Conference location Canberra, ACT, Australia
Conference dates 27-30 January 2009
Proceedings title Proceedings of: Australian Neuroscience Society Annual Meeting 2009
Publisher Australian Neuroscience Society
Publication Year 2009
Sub-type Poster
ISSN 1034-3237
Start page 69
End page 69
Total pages 1
Language eng
Formatted Abstract/Summary Purpose: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ) that causes impaired neuromuscular transmission and muscle weakness. Muscle Specific Kinase (MuSK) is recognized as the auto-antigen in about 10% of MG patients. Activation of MuSK by neural agrin is essential for acetylcholine receptor (AChR) clustering at the NMJ. Here we aimed to define the mechanisms by which anti-MuSK antibodies interfere with the postsynaptic AChR cluster.

Conclusion: Anti-MuSK auto-antibodies cross-link and activate MuSK. This somehow causes the disassembly of large pre-existing AChR clusters.
Subjects 1109 Neurosciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Presented during the Session "Development" as Poster no. POS-THU-034

Document type: Conference Paper
Collection: School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Access Statistics: 168 Abstract Views  -  Detailed Statistics
Created: Thu, 11 Nov 2010, 11:12:14 EST by Jon Swabey on behalf of Faculty Of Health Sciences