Systemic response to improved periodontal health in a cardiovascular population

Ford, P. J., Rose-Hill, S., Leishman, S. J., Do, H. L., Palmer, J. E., Heng, N. C. K., Westerman, B., West, M. J., Seymour, G. J. and Cullinan, M. P. (2010). Systemic response to improved periodontal health in a cardiovascular population. In: International Association for Dental Research (IADR) General section, Barcelona, Spain, (). 14-17 July 2010.

Author Ford, P. J.
Rose-Hill, S.
Leishman, S. J.
Do, H. L.
Palmer, J. E.
Heng, N. C. K.
Westerman, B.
West, M. J.
Seymour, G. J.
Cullinan, M. P.
Title of paper Systemic response to improved periodontal health in a cardiovascular population
Conference name International Association for Dental Research (IADR) General section
Conference location Barcelona, Spain
Conference dates 14-17 July 2010
Publication Year 2010
Sub-type Poster
Language eng
Formatted Abstract/Summary
Background: Strong evidence exists for a relationship between periodontal disease, systemic inflammatory and immune responses and cardiovascular disease (CVD). Systemic inflammation and cross-reactive immune responses to bacterial and human heat shock proteins have each been proposed as mechanisms for atherogenesis. Objectives: To examine changes in serum levels of inflammatory mediators and antibodies to Porphyromonas gingivalis, human heat shock protein 60 (hHSP60), and P.gingivalis GroEL following improvement in periodontal health in patients with CVD.

Methods: Patients (n=17) who had previously experienced a CV event and demonstrating a quantifiable improvement in periodontal health (³62% reduction in number of sites with periodontal probing depth (PPD) ³4mm) from the baseline visit to a followup visit approximately 1 year later were retrospectively selected from a longitudinal study. Serum levels of IL-1b, IL-6, TNF-a and sICAM-1, and IgG antibodies to P.gingivalis, hHSP60 and P.gingivalis GroEL were measured at baseline and after improvement in periodontal health using ELISA. Results: There were reductions in the levels of the four inflammatory markers at the followup visit and this reduction was significant for sICAM-1 (p=0.047). Most patients with detectable levels of each of the inflammatory markers at baseline showed reductions at the followup visit. Small reductions in levels of antibodies to the bacterial and human HSPs were also recorded for most patients at the second visit.

Conclusion: Patients with cardiovascular disease and who also experienced an improvement in periodontal health showed a significant reduction in mean serum levels of sICAM-1. Most patients demonstrated reductions in all inflammatory mediators measured as well as in levels of anti-heat shock protein antibodies. The significance of this in terms of reducing the risk of further CV events remains to be determined.
Subjects 11 Medical and Health Sciences
1107 Immunology
110704 Cellular Immunology
Keyword Cross-reactive immune
Human heat shock proteins
Cardiovascular disease
P.gingivalis GroEL
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: School of Medicine Publications
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Created: Mon, 08 Nov 2010, 16:00:30 EST by Hong Lien Do on behalf of Faculty Of Health Sciences