Parameters governing invasive disease propensity of non-M1 serotype group A streptococci

Maamary, PG, Sanderson-Smith, ML, Aziz, RK, Hollands, A, Cole, JN, Mckay, FC, McArthur, JD, Kirk, JK, Cork, AJ, Keefe, RJ, Kansal, RG, Sun, H, Taylor, WL, Chhatwal, GS, Ginsburg, D, Nizet, V, Kotb, M and Walker, MJ (2010) Parameters governing invasive disease propensity of non-M1 serotype group A streptococci. Journal of Innate Immunology, 2 6: 596-606. doi:10.1159/000317640

Author Maamary, PG
Sanderson-Smith, ML
Aziz, RK
Hollands, A
Cole, JN
Mckay, FC
McArthur, JD
Kirk, JK
Cork, AJ
Keefe, RJ
Kansal, RG
Sun, H
Taylor, WL
Chhatwal, GS
Ginsburg, D
Nizet, V
Kotb, M
Walker, MJ
Title Parameters governing invasive disease propensity of non-M1 serotype group A streptococci
Journal name Journal of Innate Immunology   Check publisher's open access policy
ISSN 1662-811X
Publication date 2010-10
Sub-type Article (original research)
DOI 10.1159/000317640
Volume 2
Issue 6
Start page 596
End page 606
Total pages 11
Place of publication Basel, Switzerland
Publisher S. Karger
Collection year 2011
Language eng
Formatted abstract
Group A Streptococcus (GAS) causes rare but life-threatening syndromes of necrotizing fasciitis and toxic shock-like syndrome in humans. The GAS serotype M1T1 clone has globally disseminated, and mutations in the control of virulence regulatory sensor kinase (covRS) operon correlate with severe invasive disease. Here, a cohort of non-M1 GAS was screened to determine whether mutation in covRS triggers systemic dissemination in divergent M serotypes. A GAS disease model defining parameters governing invasive propensity of differing M types is proposed. The vast majority of GAS infection is benign. Nonetheless, many divergent M types possess limited capacity to cause invasive infection. M1T1 GAS readily switch to a covRS mutant form that is neutrophil resistant and frequently associated with systemic infection. Whilst non-M1 GAS are shown in this study to less frequently accumulate covRS mutations in vivo, such mutants are isolated from invasive infections and exhibit neutrophil resistance and enhanced virulence. The reduced capacity of non-M1 GAS to switch to the hypervirulent covRS mutant form provides an explanation for the comparatively less frequent isolation of non-M1 serotypes from invasive human infections. Copyright © 2010 S. Karger AG, Basel.
Keyword Animal models
Virulence factors
Invasive infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 07 Nov 2010, 00:08:50 EST