The renin-angiotensin system and cancer: Old dog, new tricks

George, AJ, Thomas, WG and Hannan, RD (2010) The renin-angiotensin system and cancer: Old dog, new tricks. Nature Reviews Cancer, 10 11: 745-759. doi:10.1038/nrc2945


Author George, AJ
Thomas, WG
Hannan, RD
Title The renin-angiotensin system and cancer: Old dog, new tricks
Journal name Nature Reviews Cancer   Check publisher's open access policy
ISSN 1474-175X
1474-1768
Publication date 2010-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrc2945
Volume 10
Issue 11
Start page 745
End page 759
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological systems that influence cell growth, migration and death, as well as inflammation and the expansion of vascular networks are required. There is accumulating molecular and in vivo evidence to indicate that the expression and actions of the renin-angiotensin system (RAS) influence malignancy and also predict that RAS inhibitors, which are currently used to treat hypertension and cardiovascular disease, might augment cancer therapies. To appreciate this potential hegemony of the RAS in cancer, an expanded comprehension of the cellular actions of this system is needed, as well as a greater focus on translational and in vivo research. © 2010 Macmillan Publishers Limited. All rights reserved.
Keyword II type-1 receptor
Epidermal-growth-factor
Smooth-muscle-cells
Gene insertion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Biological Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 120 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 07 Nov 2010, 10:04:10 EST