Analysis of evolutionarily conserved innate immune components in coral links immunity and symbiosis

Kvennefors, E. Charlotte E., Leggat, William, Kerr, Caroline C., Ainsworth, Tracy D., Hoegh-Guldberg, Ove and Barnes, Andrew C. (2010) Analysis of evolutionarily conserved innate immune components in coral links immunity and symbiosis. Developmental and Comparative Immunology, 34 11: 1219-1229. doi:10.1016/j.dci.2010.06.016

Author Kvennefors, E. Charlotte E.
Leggat, William
Kerr, Caroline C.
Ainsworth, Tracy D.
Hoegh-Guldberg, Ove
Barnes, Andrew C.
Title Analysis of evolutionarily conserved innate immune components in coral links immunity and symbiosis
Journal name Developmental and Comparative Immunology   Check publisher's open access policy
ISSN 0145-305X
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1016/j.dci.2010.06.016
Volume 34
Issue 11
Start page 1219
End page 1229
Total pages 11
Editor G. W. Warr
K. Soderhall
Place of publication New York, U.S.A.
Publisher Pergamon
Collection year 2011
Language eng
Subject 970106 Expanding Knowledge in the Biological Sciences
060399 Evolutionary Biology not elsewhere classified
Formatted abstract
Reef-building corals are representatives of one of the earliest diverging metazoan lineages and are experiencing increases in bleaching events (breakdown of the coral-. Symbiodinium symbiosis) and disease outbreaks. The present study investigates the roles of two pattern recognition proteins, the mannose binding lectin Millectin and a complement factor C3-like protein (C3-Am), in the coral Acropora millepora. The results indicate that the innate immune functions of these molecules are conserved and arose early in evolution. C3-Am is expressed in response to injury, and may function as an opsonin. In contrast, Millectin expression is up-regulated in response to lipopolysaccharide and peptidoglycan. These observations, coupled with localization of Millectin in nematocysts in epidermal tissue, and reported binding of pathogens, are consistent with a key role for the lectin in innate immunity. Furthermore, Millectin was consistently detected binding to the symbiont Symbiodinium in vivo, indicating that the Millectin function of recognition and binding of non-self-entities may have been co-opted from an ancient innate immune system into a role in symbiosis.
© 2010 Elsevier Ltd.

Keyword Coral
Complement C3
Mannose binding lectin
Acropora millepora
Octocoral sinularia-lochmodes
Mannose-binding lectin
Dinoflagellate symbionts
Surfactant proteins
C3-like protein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Global Change Institute Publications
Official 2011 Collection
School of Biological Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 37 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 05 Nov 2010, 14:22:09 EST by Gail Walter on behalf of School of Biological Sciences